The Laboratory of Molecular Therapeutics



Postdoc Positions Available
1 / 4
Our group is interested in disrupting the amyloidogenic cascade in tauopathies and alpha-synucleinopathies. Our Cellular biosensors report on toxic-oligomers using both intermolecular and intramolecular time-resolved FRET measurements.
2 / 4
Our group is interested in disrupting the amyloidogenic cascade in tauopathies and alpha-synucleinopathies. Our Cellular biosensors report on toxic-oligomers using both intermolecular and intramolecular time-resolved FRET measurements.
3 / 4
Using molecular dynamics simulation to investigate the stability of alpha-synuclein fibrils, our group unravels key interactions within the fibril core. A T75-water wire network is important to stabilize the fibrils longitudinal axis.
4 / 4
TNFR1 and DR5

 

Overview

Our interest is in elucidating the molecular behavior of protein species relevant to the neurodegenerative framespace. To this end, we are employing a variety of techniques to study both the fluctuation behavior of some of the most elusive proteins known to science as well as their biological impact and toxicity. In pursuit of these goals, our lab also employs high-throughput library screening methodologies to identify compounds of potential therapeutic value. Currently, we are focusing our efforts on α-synuclein, the etiologic agent behind Parkinson's disease, but our breakthrough findings may have significant impact in other pathologies such as Alzheimer's and prion diseases.

 

UMN Links
Department of Biomedical Engineering
University of Minnesota
Biomedical Engineering Graduate Program
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Department of Biomedical Engineering · Hasselmo Hall, 312 Church Street S.E. Minneapolis, MN 55455