The Laboratory of Molecular Therapeutics

Amyloid cascade
IDP FRET BIosensor Design


Our interest is in elucidating the molecular behavior of protein species relevant to the neurodegenerative framespace. To this end, we are employing a variety of techniques to study both the fluctuation behavior of some of the most elusive proteins known to science as well as their biological impact and toxicity. In pursuit of these goals, our lab also employs high-throughput library screening methodologies to identify compounds of potential therapeutic value. Currently, we are focusing our efforts on α-synuclein, the etiologic agent behind Parkinson's disease, but our breakthrough findings may have significant impact in other pathologies such as Alzheimer's and prion diseases.